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This conclusion was later challenged: in a migraine rat model, oral gastrodin capsules increased AUC 0 ‒ by 45.4%, decreased clearance (CL) by 28.3%, and prolonged Tmax by 74.1%, suggesting migraine may enhance gastrodin brain exposure by affecting BBB permeability or metabolic enzyme activity ( 0 ‒ (1.042 ± 0.259 mg/mL·h) and Cmax (0.036 ± 0.010 mg/mL) in the cerebellum than in the frontal cortex, hippocampus, and thalamus, indicating preferential cerebellar targeting (Wang et al., 2008)

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Research Notice: This article covers research topics relevant to BAC Water — available from Palmetto Peptides for laboratory use only